双亲性羧甲基壳聚糖钠盐席夫碱的合成及其作为(6)

3 结 论

以壳聚糖为原料,通过取代反应和席夫碱反应合成了CMCCNa,并通过1H-NMR和元素分析对产物结构和取代度进行了表征．合成的CMCCNa均具有一定的黏性,随着取代度增加黏度有所下降;其HLB值在13.26～14.72之间,具有良好的水溶性;且CMCCNa均具备一定的抗菌能力,并随取代度的增加抗菌活性增强,其中CMCCNa-24对大肠杆菌和金黄色葡萄球菌的MIC值分别为15.6和3.9 μg/mL.炉甘石混悬剂的稳定性研究表明CMCCNa-12能够提高混悬剂的稳定性,可作为稳定剂使用．可见，CMCCNa集助悬、润湿和防腐3种功能于一体,有望成为一种多功能稳定剂．根据材料的用途,以壳聚糖为基础,采用席夫碱反应引入不同功能的天然醛类化合物是一种简便可行的设计思路．

参考文献：

[1] 崔福德,龙晓英,吕万良,等.药剂学[M].北京:人民卫生出版社,2013:152-157.

[2] 丁波,信卉.混悬剂用助悬剂的研究进展[J].中国现代药物应用,2011,5(3):231-233.

[3] 喻樊.炉甘石洗剂处方优化[J].中国实验方剂学杂志,2012,18(1):1-3.

[4] KUMAR M N,MUZZARELLI R A,MUZZARELLI C,et chemistry and pharmaceutical perspectives[J].Chem Rev,2004,104(12):6017-6084.

[5] 林水森,李明春,辛梅华,等.壳聚糖及其衍生物抗菌机理研究进展[J].化学通报,2014,77(3):220-226.

[6] ZHANG J L,XIA W S,LIU P,et modification and pharmaceutical/biomedical applications[J].Mar Drugs,2010,8(7):1962-1987.

[7] 蒋挺大.壳聚糖[M].北京:化学工业出版社,2007:245-258.

[8] CHEN X G,PARK H characteristics ofo-carboxymethyl chitosans related to the preparation conditions[J].Carbohydrate Polymers,2003,53(4):355-359.

[9] JIN X X,WANG J T,BAI and antimicrobial activity of the Schiff base from chitosan and citral[J].Carbohydrate Research,2009,344(6):825-829.

[10] 王旭颖,董安康,崔玉梅,等.壳聚糖表面活性剂的制备及其表面性能[J].日用化学工业,2011,41(3):172-175.

[11] 裴立军,蔡照胜,商士斌,等.脱氢枞胺-壳聚糖阳离子表面活性剂的合成及性能研究[J].林产化学与工业,2014,34(5):47-52.

[12] 周盛全,辛梅华,李明春,等.新型壳聚糖季铵盐抗菌剂的合成及其性能[J].化工进展,2012,31(8):1801-1805.

[13] 李红霞,张灿,尤启冬.N-辛基-N′-亚胺基-o-羧甲基壳聚糖衍生物的合成、表征与体外pH敏感性[J].中国药科大学学报,2009,40(5):385-388.

[14] 温俊杰,周莉,王紫威,等.微波法制备o-羟丙基-N-辛基壳聚糖及其性能表征[J].应用化学,2015,32(2):192-199.

[15] RAYMOND C R,PAUL J S,MARIAN E Q,et of pharmaceutical excipients[M].6th :Pharmaceutical Press,2009:119-120.

Abstract:The Schiff′s base of carboxymethyl chitosan sodium was synthesized by the reaction of carboxymethyl chitosan sodium with structure of the Schiff′s base was characterized using1H-NMR and elemental analysis,which confirmed that the amino groups in carboxymethyl chitosan reacted with citral to form the Schiff′s base.The viscosity,hydrophile-lipophile balance value and antibacterial properties of the products were also results showed that the derivatives have potential as a high polymer suspension,wetting and antibacterial properties of the products as a stabilizer of suspensions were further rate and dispersion experiments showed that the product could improve the stability of the suspensions.

文章来源：《金属功能材料》 网址: http://www.jsgncl.cn/qikandaodu/2021/0303/403.html